Efficacy of Intralesional 5-fluorouracil and Triamcinolone in the Treatment of Keloids
Joseph H. Dayan, MD, Steven P. Davison, DDS, MD,
Smitha Sonni, MD, Amy Crane, MD
Smitha Sonni, MD, Amy Crane, MD
BACKGROUND: Keloids are a
common problem with a reported incidence of 4.5 to
16 percent in darker-skinned individuals.1, 2
Intralesional triamcinolone has traditionally
been the mainstay of treatment and in conjunction with excision has yielded efficacy
rates between 58% and 93%.3-7
However there are a significant number of treatment failures and
substantial inconsistencies with regard to the reproducibility of results. Additionally, adverse effects including
hypopigmentation, atrophy, and telangiectasias have been reported to be as high
as 37% in the literature.8 The
purpose of this study is to evaluate the efficacy and adverse effects of a
5-fluorouracil/steroid mixture over the past seven years and compare the
results with steroid alone.
METHODS: All charts from
1999 to 2006 were reviewed. Patients were stratified into
three groups: 5-FU/steroid without surgical excision,
5-FU/steroid with excision, and
steroid with excision. The follow-up period ranged
from 6 months to 6 years. Percentage
size reduction and adverse effects including
telangiectasia, atrophy, hypopigmentation, and dehiscence were recorded. A mixture of 75% 5-FU and 25% Kenolog 40 was
most commonly used. 0.1 ml of solution
per centimeter of lesion was injected.
Patients undergoing concurrent excision received injections
intraoperatively and again at 2, 4, and 6 weeks post-op. Non-surgical patients received injections an
average of four weeks apart.
RESULTS: A total of 94
patients with 102 keloids were identified. Patients who
underwent excision with the 5-FU/steroid combination
had a 92% average reduction in
lesion size compared to 73% in the group of patients
who did not receive 5-FU. Patients
who received 5-FU/steroid without excision had an
average size reduction of 81%. These
differences were statistically significant (p = 0.05).
Adverse effects were higher in the
5-FU groups compared with the steroid only group (23%
and 15%, respectively),
although these results were not statistically
significant (p = 0.62). The most common
side effect was telangiectasia.
CONCLUSIONS: Although
this study is limited by its retrospective nature, the results in this study,
the supporting basic science data, and anecdotal reports suggest combination
5-FU/triamcinolone may be superior in efficacy compared to intralesional
steroid therapy.9-16 The
successes of 5-FU in those particularly intractable keloid cases where steroids
have failed is significant.
Interestingly, the side effect profile was not lower in the 5-FU
group. However, we speculate the telangiectasias
and atrophy were likely caused by the steroid component. Thus, we are prospectively studying the
effects of 5-FU with a lower triamcinolone dose. Long-term prospective trials using
anti-neoplastic agents are needed to properly establish an ideal treatment
regimen for this challenging problem.
A keloid scar is an enlarged, raised scar that may be pink, pink, pores and skin-coloured or darker than the encompassing skin.Keloid Treatment In Dubai They can increase after very minor skin damage, which includes an zits spot or a piercing, and unfold past the authentic vicinity of pores and skin damage.
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