Genetic Terms and Definitions
Alleles: Alternative forms of a genetic locus;
a single allele for each locus is inherited separately from each parent (e.g.,
at a locus for eye color the allele might result in blue or brown eyes).
Amino acid: Any of a class of 20 molecules
that are combined to form proteins in living things. The sequence of
amino acids in a protein and hence protein function are determined by the genetic
code.
Autosome: A chromosome not involved
in sex determination. The diploid human genome consists of 46
chromosomes, 22 pairs of autosomes, and 1 pair of sex chromosomes (the X
and Y chromosomes).
Base pair (bp): Two
nitrogenous bases (adenine and thymine or guanine and cytosine)
held together by weak bonds. Two strands of DNA are held together in the shape
of a double helix by the bonds between base pairs.
Base sequence: The order of nucleotide
bases in a DNA molecule.
Centromere: A
specialized chromosome region to which spindle fibers attach during cell
division.
Chromosomes: The
self- replicating genetic structures of cells containing the cellular DNA that
bears in its nucleotide sequence the linear array of genes. In prokaryotes,
chromosomal DNA is circular, and the entire genome is carried on one
chromosome. Eukaryotic genomes consist of a number of chromosomes whose
DNA is associated with different kinds of proteins.
Cloning: The process
of asexually producing a group of cells (clones), all genetically identical,
from a single ancestor.
Crossing
over: The breaking during meiosis
of one maternal and one paternal chromosome, the exchange of
corresponding sections of DNA, and the rejoining of the chromosomes. This
process can result in an exchange of alleles between chromosomes. Compare recombination.
Diploid: A full set of genetic material,
consisting of paired chromosomes one chromosome from each parental set.
Most animal cells except the gametes have a diploid set of chromosomes.
The diploid human genome has 46 chromosomes. Compare haploid.
DNA (deoxyribonucleic acid): The molecule that encodes genetic information. DNA is a double- stranded molecule held together by weak bonds between base pairs
of nucleotides. The four nucleotides in DNA contain the bases: adenine
(A), guanine (G), cytosine (C), and thymine (T). In
nature, base pairs form only between A and T and between G and C; thus
the base sequence of each single strand can be deduced from that of its
partner.
DNA replication: The use
of existing DNA as a template for the synthesis of new DNA strands. In humans
replication occurs in the cell nucleus.
DNA sequence: The
relative order of base pairs, whether in a fragment of DNA, a gene,
a chromosome, or an entire genome. See base sequence analysis.
Dominant: A gene which is always expressed when present
Double helix: The
shape that two linear strands of DNA assume when bonded together.
F1
(Cross) Hybrids: A cross between two pure bred lines producing
offspring with desirable characteristics and hybrid vigour
Gamete: Mature male or female
reproductive cell (sperm or ovum) with a haploid set of chromosomes
(23 for humans).
Gene: The fundamental physical and
functional unit of heredity. A gene is an ordered sequence of nucleotides
located in a particular position on a particular chromosome that encodes
a specific functional product (i.e., a protein or RNA molecule).
See gene expression.
Genetics: The study of the patterns of
inheritance of specific traits.
Genetic Modification: The
altering of the genetic mak-up of an organism to produce esirale traits
Genome: All the genetic material in the chromosomes
of a particular organism; its size is generally given as its total number of base
pairs.
Genome
projects: Research
and technology development efforts aimed at mapping and sequencing
some or all of the genome of human beings and other organisms.
Guanine
(G): A
nitrogenous base, one member of the base pair G- C (guanine and cytosine).
Haploid: A single set of chromosomes
(half the full set of genetic material), present in the egg and sperm cells of
animals and in the egg and pollen cells of plants. Human beings have 23
chromosomes in their reproductive cells. Compare diploid.
Heterozygous:
When the genes for a particular gene are
different.
Homozygous: When
the genes for a particular trait are the same
Homologous chromosomes: A pair of chromosomes
containing the same linear gene sequences, each derived from one parent.
Human
gene therapy: Insertion of normal DNA directly into cells to correct a genetic
defect.
Interphase: The period in the cell cycle
when DNA is replicated in the nucleus; followed by mitosis.
Incomplete Dominance: Occurs
when neither allele is dominant over the other and the resultant phenotype is a
mix of the two gene traits.
Linkage: The proximity of two or more genes
on a chromosome; the closer together the markers are, the lower the
probability that they will be separated during DNA repair or replication
processes (binary fission in prokaryotes, mitosis or meiosis in eukaryotes),
and hence the greater the probability that they will be inherited together.
Locus (pl. loci): The position on a chromosome
of a gene or other chromosome marker; also, the DNA at that
position. The use of locus is sometimes restricted to mean regions of
DNA that are expressed. See gene expression.
Meiosis: The process of two consecutive
cell divisions in the diploid progenitors of sex cells. Meiosis results
in four rather than two daughter cells, each with a haploid set of chromosomes.
Metaphase: A stage
in mitosis or meiosis during which the chromosomes are
aligned along the equatorial plane of the cell.
Mitosis: The process of nuclear division in cells that
produces daughter cells that are genetically identical to each other and to the
parent cell.
Mutation: Any heritable change in DNA sequence.
Multiple
Alleles: Many
different forms of the same gene e.g. Eye colour
Nucleic
acid: A large
molecule composed of nucleotide subunits.
Nucleotide: A subunit of DNA or RNA
consisting of a nitrogenous base (adenine, guanine, thymine, or cytosine
in DNA; adenine, guanine, uracil, or cytosine in RNA), a phosphate
molecule, and a sugar molecule (deoxyribose in DNA and ribose in RNA).
Thousands of nucleotides are linked to form a DNA or RNA molecule. See DNA,
base pair, RNA.
Nucleus: The cellular organelle in eukaryotes
that contains the genetic material.
Performance testing: A
comparison of growth rates of animals under similar conditions
Phenotype:
The physical expression of the genotype (i.e. Bb
gives brown)
Polyploidy:
Having three or more sets of chromosomes which
generally leads to infertility
Progeny
Testing: Testing of the performance of offspring relative to
their parents
Prokaryote: Cell or organism lacking a
membrane- bound, structurally discrete nucleus. Bacteria are
prokaryotes. Compare eukaryote. See chromosomes.
Recessive:
A gene that is not expressed in the presence of a
dominant gene
Ribosomes: Small cellular components composed of specialized
ribosomal RNA and protein; site of protein synthesis. See ribonucleic acid
(RNA).
Sex
chromosomes: The X
and Y chromosomes in human beings that determine the sex of an
individual. Females have two X chromosomes in diploid cells; males have an X
and a Y chromosome. The sex chromosomes comprise the 23rd chromosome pair in a karyotype.
Compare autosome.
Sex Linkage: The
inheritance of genes which are located on the X chromosome.
Somatic
cells: Any cell
in the body except gametes and their precursors.
Transcription: The synthesis of an RNA
copy from a sequence of DNA (a gene); the first step in gene
expression. Compare translation.
Transfer
RNA (tRNA): A class of RNA having structures with
triplet nucleotide sequences that are complementary to the
triplet nucleotide coding sequences of mRNA. The role of tRNAs in
protein synthesis is to bond with amino acids and transfer them to the
ribosomes, where proteins are assembled according to the genetic code carried
by mRNA.
Transformation: A process by which the genetic
material carried by an individual cell is altered by incorporation of exogenous
DNA into its genome.
Translation: The process in which the genetic
code carried by mRNA directs the synthesis of proteins from amino acids.
Compare transcription.
Uracil: A
nitrogenous base normally found in RNA but not DNA; uracil is capable of
forming a base pair with adenine.
Variation:
Differences amongst individuals of the same species.
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