Principles of treatment of pathological pain

Read Also

The basic principle of treatment of pathological pain is nociceptive neurons suppressing hyperactivity and formed by them and generators to eliminate pathological algic system underlying the pain.

This object is achieved by a combination of two effects: 1) the impact on the non-specific standard basic processes hyperactivation of neurons, formation and activity of the generator, which is fundamentally the same in different parts of the central nervous system; 2) the impact on specific neurochemical processes which are associated with the activity of nociceptive neurons, generators and various pathological nociceptive system (pathological algic system).

Correction of the basic processes of hyperactivity of neurons and the formation of the generator may be effected by anticonvulsants (antiepileptics). Thus, a high therapeutic effect is the use of the antiepileptic drug carbamazepine (Tegretol, finlepsin) for the treatment of trigeminal neuralgia and other pain syndromes, especially acute paroxysmal character. Suppress some pain syndromes and other anticonvulsants.

Of paramount importance for the suppression of hyperactivity nociceptive neurons has blockade of admission to their Ca2 +, which is carried out by means of Ca2 + antagonists.

Since nociceptive and antinociceptive effects are realized at different levels, and that not one, but several mediators, it is advisable to use complex pathogenetic therapy in the form of a combined impact on the different links of the pathological algic system with the aim of suppression and antinociceptive system in order to activate it. Furthermore, it is also important influence on the psycho-emotional, vascular and other vegetative tissue components and pathological pain. It is necessary to eliminate the effect of the etiological factor that supports the pathological changes in the nociceptive system.