Structural and functional organization and activity of pathological features of the system
The key control element is a determinant of its
pathological hyperactivation mechanism in the form of a generator. Intermediate
and central efferent links develop an activity that corresponds to the
peculiarities of the activity of pathological determinants. If abnormal system
has access to the periphery, in its structure includes a peripheral body, which
becomes the target organ. In this case, the pathological activity of the system
is manifested in the form of altered organ function - pathological effect. If
the final link in the system is abnormal brain structure, then its effect is in
violation of the relevant functions of the brain.
From all parts of the system are abnormal negative
feedback to the same links and determinant. However, in contrast to the
physiological system, where such ties to regulate the activities of the system,
in a pathological system functionally they are ineffective because they do not
correcting (or correcting bad) pathological determinant that is due to
insufficient brake out of control. Brakes relatively scarce in other parts of
the pathological system. Therefore, the system as a whole is almost getting out
of the total CNS integrative control. At the same time, thanks to the constant
activity of the positive connection between the parts of system consolidates
pathological, conduction of excitation in these relations easier. As a result,
over time, abnormal system is becoming more resistant to regulatory influences
on the part of anti-system and the brain, and in general to the treatment
modality.
In the early stages of the pathological system
after pathological determinant activated by specific stimuli for her, in the
later stages, it can be activated by different, including random stimuli, and
spontaneously. Therefore, in the later stages of the attacks that are typical
of the activity of this pathological system (eg, seizures, emotional affects,
twinges, etc.), Can be triggered by different stimuli occur spontaneously,
becoming more frequent, persistent and intense.
In the initial stage of a pathological system
dependent on the pathological determinants, it is activated when excited
determinants and disappears when its liquidation. In the later stages due to
the consolidation of the pathological structure of the system is less dependent
on the last determinants and can continue to operate and after its removal.
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