Violation of axonal transport and dendrites

Read Also

Axonal transport from the cell body to the nerve endings and nerve endings of the neuron in the body is carried out with the participation of neurofilaments, microtubules and actin contractile proteins and miosinosimilar, reduction depends on the content of Ca2 + in the environment and energy from ATP cleavage. The substances, which destroy microtubules and neurofilaments (colchicine, vinblastine, etc.), Lack of ATP, metabolic poisons, creating an energy deficit (dinitrophenol, cyanide), violate axo- flow. Axonal transport suffers from axon degeneration, caused by lack of vitamin B6 and vitamin B (beri-beri), industrial poisons (acrylamide hexachlorophorum), salts of heavy metals (lead), pharmacological drugs (disulfiram), alcohol, diabetes, nerve compression and dystrophic neuronal damage. When a break occurs Wallerian axon degeneration (decay) of its peripheral parts and retrograde degeneration of the central part. These processes involve a violation trophism in both parts of the axon.

Disorders of axonal transport trophogenic and substances necessary for the formation and release of mediators of nerve endings that cause the development of degenerative changes of neurons and innervated tissues and disruption of synaptic processes. Distribution pathotrophogenic with axonal transport, antibodies to neural tissue and neurotransmitters leads to the involvement of a pathological process in other neurons depatment CNS.

Dendrites and spines are the most vulnerable structures of the neuron. With aging spines and dendritic branches are reduced, in some degenerative diseases of the brain and atrophic (senile dementia, Alzheimer's disease), they disappear. Dendrospinule apparatus suffers from hypoxia, ischemia, concussion of the brain, stress and neurotic effects.