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Boys will be boys and girls will be girls.

 I hope I have been able  to make the point that the detailed analysis of sex differences in brain pathology is of tremendous help in understanding (or at least in thinking neurobiologically about) basic mechanisms of sex differences in normal behavior, and vice versa.  On the other hand,  the sexes usually only differ in the degree to which they are at risk for various disorders.  Most of these sex differences are clear enough to suggest ideas for a (relatively) specific mechanism,  but are too subtle to serve as unequivocal analogs of general sex differences in behavior and psychic make-up.   Suppose then that a given psychopathology affected women ten times more than men,  and that another affected men ten times more than women.  Suppose that these two psychopathologies were the two most sexually-segregated of all.    Then wouldn't it be interesting to see whether these two psychopathological states represent a sort of morbid exaggeration of the female and male psyche ?  Wouldn't it also be plausible that the endocrine and neural determinants of such disorders be overdetermined, i.e., lined up in a way which combines practically all the modulations (vectors) in a sexually dimorphic manner ?  It so happens that this is exactly what presents itself to us.   Anorexia nervosa affects ten times more women than men and psychopathy affects ten times more men than women.  No two psychopathologies are more sexually segregated.   Endocrinologically and neuropathologically,   these two diseases comprise basically all of the traits characteristic of the other sexually segregated disorders.   In other words,  the biological sex-specific determinants of these disorders are overdetermined (multiple).    The sexual segregation is so important in these two disorders that contrary to just about every other behavior or psychic syndrome known,  the sex-related biological factors are actually more important (explain more variance) than the hereditary factors.  In these cases, despite the extreme sexual segregation, the mode of hereditary transmission is fact autosomal rather than gonosomal. 

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